Pathways
NF-KappaB (p50-p65) Pathway
 Pathway.jpg "NF-KappaB (p50-p65) Pathway")
Description:
Nuclear factor-kappaB (NF-kappaB) comprises a family of transcription factors that regulate the expression of genes encoding proteins and microRNAs (miRNA, miR) precursors and may regulate a variety of biological processes such as inflammation, immunity, cell proliferation, differentiation, survival, cancer development, and progression (Ref.1, 2 and 3). NF-kappaB is ubiquitously expressed and responds to diverse stimuli, including infectious agents, cytokines, or growth factors. NF-kappaB /Rel family include five members, nam...
References:
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The NF-kappaB family of transcription factors and its regulation.
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034. doi: 10.1101/cshperspect.a000034. Review. -
Roles of NF-êB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.
Biomedicines. 2018 Mar 30;6(2). pii: E40. doi: 10.3390/biomedicines6020040. Review. -
NF-êB-IKKâ pathway as a target for drug development: realities, challenges and perspectives.
Curr Drug Targets. 2018 Feb 19. doi: 10.2174/1389450119666180219120534. [Epub ahead of print] -
Subunit-Specific Role of NF-êB in Cancer.
Biomedicines. 2018 Apr 17;6(2). pii: E44. doi: 10.3390/biomedicines6020044. Review.
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